HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
Identifieur interne : 003280 ( Main/Exploration ); précédent : 003279; suivant : 003281HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
Auteurs : Michael J. Ombrello [États-Unis] ; Elaine F. Remmers [États-Unis] ; Ioanna Tachmazidou [Royaume-Uni] ; Alexei Grom [États-Unis] ; Dirk Foell [Allemagne] ; Johannes-Peter Haas [Allemagne] ; Alberto Martini [Italie] ; Marco Gattorno [Italie] ; Seza Özen [Turquie] ; Sampath Prahalad [États-Unis] ; Andrew S. Zeft [États-Unis] ; John F. Bohnsack [États-Unis] ; Elizabeth D. Mellins [États-Unis] ; Norman T. Ilowite [États-Unis] ; Ricardo Russo [Argentine] ; Claudio Len [Brésil] ; Maria Odete E. Hilario [Brésil] ; Sheila Oliveira [Brésil] ; Rae S. M. Yeung [Canada] ; Alan Rosenberg [Canada] ; Lucy R. Wedderburn [Royaume-Uni] ; Jordi Anton [Espagne] ; Tobias Schwarz [Allemagne] ; Anne Hinks [Royaume-Uni] ; Yelda Bilginer [Turquie] ; Jane Park [États-Unis] ; Joanna Cobb [Royaume-Uni] ; Colleen L. Satorius [États-Unis] ; Buhm Han [États-Unis, Corée du Sud] ; Elizabeth Baskin [États-Unis] ; Sara Signa [Italie] ; Richard H. Duerr [États-Unis] ; J. P. Achkar [États-Unis] ; M. Ilyas Kamboh [États-Unis] ; Kenneth M. Kaufman [États-Unis] ; Leah C. Kottyan [États-Unis] ; Dalila Pinto [États-Unis] ; Stephen W. Scherer [Canada] ; Marta E. Alarc N-Riquelme [États-Unis, Espagne] ; Elisa Docampo [Belgique, Espagne] ; Xavier Estivill [Espagne] ; Ahmet Gül [Turquie] ; Paul I. W. De Bakker [Pays-Bas] ; Soumya Raychaudhuri [Royaume-Uni, États-Unis] ; Carl D. Langefeld [États-Unis] ; Susan Thompson [États-Unis] ; Eleftheria Zeggini [Royaume-Uni] ; Wendy Thomson [Royaume-Uni] ; Daniel L. Kastner [États-Unis] ; Patricia Woo [Royaume-Uni]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.
Abstract
To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA was
Url:
DOI: 10.1073/pnas.1520779112
PubMed: 26598658
PubMed Central: 4702958
Affiliations:
- Allemagne, Argentine, Belgique, Brésil, Canada, Corée du Sud, Espagne, Italie, Pays-Bas, Royaume-Uni, Turquie, États-Unis
- Angleterre, Bavière, Californie, Caroline du Nord, Catalogne, District de Basse-Franconie, District de Münster, Grand Londres, Grand Manchester, Géorgie (États-Unis), Maryland, Massachusetts, Ohio, Oklahoma, Ontario, Pennsylvanie, Province de Liège, Rhénanie-du-Nord-Westphalie, Utah, État de New York
- Barcelone, Liège, Londres, Manchester, Münster, Toronto, Wurtzbourg
- University College de Londres, Université de Barcelone, Université de Liège, Université de Manchester, Université de Toronto
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Le document en format XML
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Ombrello</name><affiliation wicri:level="2"><nlm:aff id="aff1">Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Remmers, Elaine F" sort="Remmers, Elaine F" uniqKey="Remmers E" first="Elaine F." last="Remmers">Elaine F. Remmers</name><affiliation wicri:level="2"><nlm:aff id="aff2">Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Tachmazidou, Ioanna" sort="Tachmazidou, Ioanna" uniqKey="Tachmazidou I" first="Ioanna" last="Tachmazidou">Ioanna Tachmazidou</name><affiliation wicri:level="1"><nlm:aff id="aff3">Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Grom, Alexei" sort="Grom, Alexei" uniqKey="Grom A" first="Alexei" last="Grom">Alexei Grom</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Foell, Dirk" sort="Foell, Dirk" uniqKey="Foell D" first="Dirk" last="Foell">Dirk Foell</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Haas, Johannes Peter" sort="Haas, Johannes Peter" uniqKey="Haas J" first="Johannes-Peter" last="Haas">Johannes-Peter Haas</name><affiliation wicri:level="1"><nlm:aff id="aff7">German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen</wicri:regionArea><wicri:noRegion>82467 Garmisch-Partenkirchen</wicri:noRegion><wicri:noRegion>82467 Garmisch-Partenkirchen</wicri:noRegion><wicri:noRegion>82467 Garmisch-Partenkirchen</wicri:noRegion></affiliation></author><author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pediatrics, University of Genova, 16145 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pediatrics, University of Genova, 16145 Genoa</wicri:regionArea><wicri:noRegion>16145 Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Gattorno, Marco" sort="Gattorno, Marco" uniqKey="Gattorno M" first="Marco" last="Gattorno">Marco Gattorno</name><affiliation wicri:level="1"><nlm:aff id="aff9">Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Ozen, Seza" sort="Ozen, Seza" uniqKey="Ozen S" first="Seza" last="Özen">Seza Özen</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara</wicri:regionArea><wicri:noRegion>06100 Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Prahalad, Sampath" sort="Prahalad, Sampath" uniqKey="Prahalad S" first="Sampath" last="Prahalad">Sampath Prahalad</name><affiliation wicri:level="2"><nlm:aff id="aff11">Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Pediatrics, Emory University School of Medicine, Atlanta</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff12">Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Human Genetics, Emory University School of Medicine, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Zeft, Andrew S" sort="Zeft, Andrew S" uniqKey="Zeft A" first="Andrew S." last="Zeft">Andrew S. Zeft</name><affiliation wicri:level="2"><nlm:aff id="aff13">Department of Pediatrics, Cleveland Clinic, Cleveland, OH 44195;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Bohnsack, John F" sort="Bohnsack, John F" uniqKey="Bohnsack J" first="John F." last="Bohnsack">John F. Bohnsack</name><affiliation wicri:level="2"><nlm:aff id="aff14">Department of Pediatrics, University of Utah, Salt Lake City, UT 84113;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Pediatrics, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Mellins, Elizabeth D" sort="Mellins, Elizabeth D" uniqKey="Mellins E" first="Elizabeth D." last="Mellins">Elizabeth D. Mellins</name><affiliation wicri:level="2"><nlm:aff id="aff15">Department of Pediatrics, Stanford University, Stanford, CA 94305;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Ilowite, Norman T" sort="Ilowite, Norman T" uniqKey="Ilowite N" first="Norman T." last="Ilowite">Norman T. Ilowite</name><affiliation wicri:level="2"><nlm:aff id="aff16">Department of Pediatrics, Albert Einstein College of Medicine and Children’s Hospital at Montefiore, Bronx, NY 10461;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pediatrics, Albert Einstein College of Medicine and Children’s Hospital at Montefiore, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Russo, Ricardo" sort="Russo, Ricardo" uniqKey="Russo R" first="Ricardo" last="Russo">Ricardo Russo</name><affiliation wicri:level="1"><nlm:aff id="aff17">Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires, Argentina;</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires</wicri:regionArea><wicri:noRegion>C1245AAM Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Len, Claudio" sort="Len, Claudio" uniqKey="Len C" first="Claudio" last="Len">Claudio Len</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001</wicri:regionArea><wicri:noRegion>04021-001</wicri:noRegion></affiliation></author><author><name sortKey="Hilario, Maria Odete E" sort="Hilario, Maria Odete E" uniqKey="Hilario M" first="Maria Odete E." last="Hilario">Maria Odete E. Hilario</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001</wicri:regionArea><wicri:noRegion>04021-001</wicri:noRegion></affiliation></author><author><name sortKey="Oliveira, Sheila" sort="Oliveira, Sheila" uniqKey="Oliveira S" first="Sheila" last="Oliveira">Sheila Oliveira</name><affiliation wicri:level="1"><nlm:aff id="aff19">Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901</wicri:regionArea><wicri:noRegion>21941-901</wicri:noRegion></affiliation></author><author><name sortKey="Yeung, Rae S M" sort="Yeung, Rae S M" uniqKey="Yeung R" first="Rae S. M." last="Yeung">Rae S. M. Yeung</name><affiliation wicri:level="4"><nlm:aff id="aff20">Department of Pediatrics, University of Toronto, Toronto, Canada M5S 1A8;</nlm:aff><country>Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff21">Department of Immunology, University of Toronto, Toronto, Canada M5S 1A8;</nlm:aff><country>Canada</country><wicri:regionArea>Department of Immunology, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff22">Institute of Medical Science, University of Toronto, Toronto, Canada M5S 1A8;</nlm:aff><country>Canada</country><wicri:regionArea>Institute of Medical Science, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rosenberg, Alan" sort="Rosenberg, Alan" uniqKey="Rosenberg A" first="Alan" last="Rosenberg">Alan Rosenberg</name><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada S7N 0W8;</nlm:aff><country>Canada</country><wicri:regionArea>Department of Pediatrics, University of Saskatchewan, Saskatoon</wicri:regionArea><wicri:noRegion>Saskatoon</wicri:noRegion></affiliation></author><author><name sortKey="Wedderburn, Lucy R" sort="Wedderburn, Lucy R" uniqKey="Wedderburn L" first="Lucy R." last="Wedderburn">Lucy R. Wedderburn</name><affiliation wicri:level="4"><nlm:aff id="aff24">Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Child Health, University College London, London, WC1N 1EH</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff25">Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Anton, Jordi" sort="Anton, Jordi" uniqKey="Anton J" first="Jordi" last="Anton">Jordi Anton</name><affiliation wicri:level="4"><nlm:aff id="aff26">Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Schwarz, Tobias" sort="Schwarz, Tobias" uniqKey="Schwarz T" first="Tobias" last="Schwarz">Tobias Schwarz</name><affiliation wicri:level="3"><nlm:aff id="aff27">Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Hinks, Anne" sort="Hinks, Anne" uniqKey="Hinks A" first="Anne" last="Hinks">Anne Hinks</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Bilginer, Yelda" sort="Bilginer, Yelda" uniqKey="Bilginer Y" first="Yelda" last="Bilginer">Yelda Bilginer</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara</wicri:regionArea><wicri:noRegion>06100 Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jane" sort="Park, Jane" uniqKey="Park J" first="Jane" last="Park">Jane Park</name><affiliation wicri:level="2"><nlm:aff id="aff15">Department of Pediatrics, Stanford University, Stanford, CA 94305;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Cobb, Joanna" sort="Cobb, Joanna" uniqKey="Cobb J" first="Joanna" last="Cobb">Joanna Cobb</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff29">National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Satorius, Colleen L" sort="Satorius, Colleen L" uniqKey="Satorius C" first="Colleen L." last="Satorius">Colleen L. Satorius</name><affiliation wicri:level="2"><nlm:aff id="aff2">Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Han, Buhm" sort="Han, Buhm" uniqKey="Han B" first="Buhm" last="Han">Buhm Han</name><affiliation wicri:level="2"><nlm:aff id="aff30">Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff31">Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736, Republic of Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736</wicri:regionArea><wicri:noRegion>138-736</wicri:noRegion></affiliation></author><author><name sortKey="Baskin, Elizabeth" sort="Baskin, Elizabeth" uniqKey="Baskin E" first="Elizabeth" last="Baskin">Elizabeth Baskin</name><affiliation wicri:level="2"><nlm:aff id="aff1">Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Signa, Sara" sort="Signa, Sara" uniqKey="Signa S" first="Sara" last="Signa">Sara Signa</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pediatrics, University of Genova, 16145 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pediatrics, University of Genova, 16145 Genoa</wicri:regionArea><wicri:noRegion>16145 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><affiliation wicri:level="2"><nlm:aff id="aff33">Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff34">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Achkar, J P" sort="Achkar, J P" uniqKey="Achkar J" first="J. P." last="Achkar">J. P. Achkar</name><affiliation wicri:level="2"><nlm:aff id="aff35">Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff36">Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathobiology, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><affiliation wicri:level="2"><nlm:aff id="aff33">Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Kaufman, Kenneth M" sort="Kaufman, Kenneth M" uniqKey="Kaufman K" first="Kenneth M." last="Kaufman">Kenneth M. Kaufman</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Kottyan, Leah C" sort="Kottyan, Leah C" uniqKey="Kottyan L" first="Leah C." last="Kottyan">Leah C. Kottyan</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Pinto, Dalila" sort="Pinto, Dalila" uniqKey="Pinto D" first="Dalila" last="Pinto">Dalila Pinto</name><affiliation wicri:level="2"><nlm:aff id="aff37">Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, NY 10029;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Scherer, Stephen W" sort="Scherer, Stephen W" uniqKey="Scherer S" first="Stephen W." last="Scherer">Stephen W. Scherer</name><affiliation wicri:level="1"><nlm:aff id="aff38">The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4</wicri:regionArea><wicri:noRegion>M5G 0A4</wicri:noRegion></affiliation></author><author><name sortKey="Alarc N Riquelme, Marta E" sort="Alarc N Riquelme, Marta E" uniqKey="Alarc N Riquelme M" first="Marta E." last="Alarc N-Riquelme">Marta E. Alarc N-Riquelme</name><affiliation wicri:level="2"><nlm:aff id="aff39">Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40">Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016</wicri:regionArea><wicri:noRegion>PTS Granada 18016</wicri:noRegion></affiliation></author><author><name sortKey="Docampo, Elisa" sort="Docampo, Elisa" uniqKey="Docampo E" first="Elisa" last="Docampo">Elisa Docampo</name><affiliation wicri:level="4"><nlm:aff id="aff41">Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège</wicri:regionArea><placeName><region type="province" nuts="2">Province de Liège</region><settlement type="city">Liège</settlement><settlement type="city">Liège</settlement></placeName><orgName type="university">Université de Liège</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42">Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name><affiliation wicri:level="1"><nlm:aff id="aff42">Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gul, Ahmet" sort="Gul, Ahmet" uniqKey="Gul A" first="Ahmet" last="Gül">Ahmet Gül</name><affiliation wicri:level="1"><nlm:aff id="aff43">Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey;</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul</wicri:regionArea><wicri:noRegion>34390 Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="1"><nlm:aff id="aff44">Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX</wicri:regionArea><wicri:noRegion>3584 CX</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX</wicri:regionArea><wicri:noRegion>3584 CX</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff46">Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX</wicri:regionArea><wicri:noRegion>3584 CX</wicri:noRegion></affiliation></author><author><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff30">Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff31">Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Langefeld, Carl D" sort="Langefeld, Carl D" uniqKey="Langefeld C" first="Carl D." last="Langefeld">Carl D. Langefeld</name><affiliation wicri:level="2"><nlm:aff id="aff47">Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Susan" sort="Thompson, Susan" uniqKey="Thompson S" first="Susan" last="Thompson">Susan Thompson</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name><affiliation wicri:level="1"><nlm:aff id="aff3">Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Thomson, Wendy" sort="Thomson, Wendy" uniqKey="Thomson W" first="Wendy" last="Thomson">Wendy Thomson</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff29">National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Kastner, Daniel L" sort="Kastner, Daniel L" uniqKey="Kastner D" first="Daniel L." last="Kastner">Daniel L. Kastner</name><affiliation wicri:level="2"><nlm:aff id="aff2">Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Woo, Patricia" sort="Woo, Patricia" uniqKey="Woo P" first="Patricia" last="Woo">Patricia Woo</name><affiliation wicri:level="4"><nlm:aff id="aff25">Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26598658</idno><idno type="pmc">4702958</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702958</idno><idno type="RBID">PMC:4702958</idno><idno type="doi">10.1073/pnas.1520779112</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000232</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000232</idno><idno type="wicri:Area/Pmc/Curation">000232</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000232</idno><idno type="wicri:Area/Pmc/Checkpoint">001246</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001246</idno><idno type="wicri:Area/Ncbi/Merge">002D78</idno><idno type="wicri:Area/Ncbi/Curation">002D78</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D78</idno><idno type="wicri:Area/Main/Merge">003281</idno><idno type="wicri:Area/Main/Curation">003280</idno><idno type="wicri:Area/Main/Exploration">003280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>HLA-DRB1*11</italic> and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis</title><author><name sortKey="Ombrello, Michael J" sort="Ombrello, Michael J" uniqKey="Ombrello M" first="Michael J." last="Ombrello">Michael J. Ombrello</name><affiliation wicri:level="2"><nlm:aff id="aff1">Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Remmers, Elaine F" sort="Remmers, Elaine F" uniqKey="Remmers E" first="Elaine F." last="Remmers">Elaine F. Remmers</name><affiliation wicri:level="2"><nlm:aff id="aff2">Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Tachmazidou, Ioanna" sort="Tachmazidou, Ioanna" uniqKey="Tachmazidou I" first="Ioanna" last="Tachmazidou">Ioanna Tachmazidou</name><affiliation wicri:level="1"><nlm:aff id="aff3">Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Grom, Alexei" sort="Grom, Alexei" uniqKey="Grom A" first="Alexei" last="Grom">Alexei Grom</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Foell, Dirk" sort="Foell, Dirk" uniqKey="Foell D" first="Dirk" last="Foell">Dirk Foell</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Haas, Johannes Peter" sort="Haas, Johannes Peter" uniqKey="Haas J" first="Johannes-Peter" last="Haas">Johannes-Peter Haas</name><affiliation wicri:level="1"><nlm:aff id="aff7">German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen</wicri:regionArea><wicri:noRegion>82467 Garmisch-Partenkirchen</wicri:noRegion><wicri:noRegion>82467 Garmisch-Partenkirchen</wicri:noRegion><wicri:noRegion>82467 Garmisch-Partenkirchen</wicri:noRegion></affiliation></author><author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pediatrics, University of Genova, 16145 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pediatrics, University of Genova, 16145 Genoa</wicri:regionArea><wicri:noRegion>16145 Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Gattorno, Marco" sort="Gattorno, Marco" uniqKey="Gattorno M" first="Marco" last="Gattorno">Marco Gattorno</name><affiliation wicri:level="1"><nlm:aff id="aff9">Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa</wicri:regionArea><wicri:noRegion>16147 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Ozen, Seza" sort="Ozen, Seza" uniqKey="Ozen S" first="Seza" last="Özen">Seza Özen</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara</wicri:regionArea><wicri:noRegion>06100 Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Prahalad, Sampath" sort="Prahalad, Sampath" uniqKey="Prahalad S" first="Sampath" last="Prahalad">Sampath Prahalad</name><affiliation wicri:level="2"><nlm:aff id="aff11">Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Pediatrics, Emory University School of Medicine, Atlanta</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff12">Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Human Genetics, Emory University School of Medicine, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Zeft, Andrew S" sort="Zeft, Andrew S" uniqKey="Zeft A" first="Andrew S." last="Zeft">Andrew S. Zeft</name><affiliation wicri:level="2"><nlm:aff id="aff13">Department of Pediatrics, Cleveland Clinic, Cleveland, OH 44195;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Bohnsack, John F" sort="Bohnsack, John F" uniqKey="Bohnsack J" first="John F." last="Bohnsack">John F. Bohnsack</name><affiliation wicri:level="2"><nlm:aff id="aff14">Department of Pediatrics, University of Utah, Salt Lake City, UT 84113;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Department of Pediatrics, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Mellins, Elizabeth D" sort="Mellins, Elizabeth D" uniqKey="Mellins E" first="Elizabeth D." last="Mellins">Elizabeth D. Mellins</name><affiliation wicri:level="2"><nlm:aff id="aff15">Department of Pediatrics, Stanford University, Stanford, CA 94305;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Ilowite, Norman T" sort="Ilowite, Norman T" uniqKey="Ilowite N" first="Norman T." last="Ilowite">Norman T. Ilowite</name><affiliation wicri:level="2"><nlm:aff id="aff16">Department of Pediatrics, Albert Einstein College of Medicine and Children’s Hospital at Montefiore, Bronx, NY 10461;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pediatrics, Albert Einstein College of Medicine and Children’s Hospital at Montefiore, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Russo, Ricardo" sort="Russo, Ricardo" uniqKey="Russo R" first="Ricardo" last="Russo">Ricardo Russo</name><affiliation wicri:level="1"><nlm:aff id="aff17">Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires, Argentina;</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires</wicri:regionArea><wicri:noRegion>C1245AAM Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Len, Claudio" sort="Len, Claudio" uniqKey="Len C" first="Claudio" last="Len">Claudio Len</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001</wicri:regionArea><wicri:noRegion>04021-001</wicri:noRegion></affiliation></author><author><name sortKey="Hilario, Maria Odete E" sort="Hilario, Maria Odete E" uniqKey="Hilario M" first="Maria Odete E." last="Hilario">Maria Odete E. Hilario</name><affiliation wicri:level="1"><nlm:aff id="aff18">Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001</wicri:regionArea><wicri:noRegion>04021-001</wicri:noRegion></affiliation></author><author><name sortKey="Oliveira, Sheila" sort="Oliveira, Sheila" uniqKey="Oliveira S" first="Sheila" last="Oliveira">Sheila Oliveira</name><affiliation wicri:level="1"><nlm:aff id="aff19">Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901</wicri:regionArea><wicri:noRegion>21941-901</wicri:noRegion></affiliation></author><author><name sortKey="Yeung, Rae S M" sort="Yeung, Rae S M" uniqKey="Yeung R" first="Rae S. M." last="Yeung">Rae S. M. Yeung</name><affiliation wicri:level="4"><nlm:aff id="aff20">Department of Pediatrics, University of Toronto, Toronto, Canada M5S 1A8;</nlm:aff><country>Canada</country><wicri:regionArea>Department of Pediatrics, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff21">Department of Immunology, University of Toronto, Toronto, Canada M5S 1A8;</nlm:aff><country>Canada</country><wicri:regionArea>Department of Immunology, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff22">Institute of Medical Science, University of Toronto, Toronto, Canada M5S 1A8;</nlm:aff><country>Canada</country><wicri:regionArea>Institute of Medical Science, University of Toronto, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rosenberg, Alan" sort="Rosenberg, Alan" uniqKey="Rosenberg A" first="Alan" last="Rosenberg">Alan Rosenberg</name><affiliation wicri:level="1"><nlm:aff id="aff23">Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada S7N 0W8;</nlm:aff><country>Canada</country><wicri:regionArea>Department of Pediatrics, University of Saskatchewan, Saskatoon</wicri:regionArea><wicri:noRegion>Saskatoon</wicri:noRegion></affiliation></author><author><name sortKey="Wedderburn, Lucy R" sort="Wedderburn, Lucy R" uniqKey="Wedderburn L" first="Lucy R." last="Wedderburn">Lucy R. Wedderburn</name><affiliation wicri:level="4"><nlm:aff id="aff24">Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Child Health, University College London, London, WC1N 1EH</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff25">Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Anton, Jordi" sort="Anton, Jordi" uniqKey="Anton J" first="Jordi" last="Anton">Jordi Anton</name><affiliation wicri:level="4"><nlm:aff id="aff26">Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Schwarz, Tobias" sort="Schwarz, Tobias" uniqKey="Schwarz T" first="Tobias" last="Schwarz">Tobias Schwarz</name><affiliation wicri:level="3"><nlm:aff id="aff27">Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Hinks, Anne" sort="Hinks, Anne" uniqKey="Hinks A" first="Anne" last="Hinks">Anne Hinks</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Bilginer, Yelda" sort="Bilginer, Yelda" uniqKey="Bilginer Y" first="Yelda" last="Bilginer">Yelda Bilginer</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey;</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara</wicri:regionArea><wicri:noRegion>06100 Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jane" sort="Park, Jane" uniqKey="Park J" first="Jane" last="Park">Jane Park</name><affiliation wicri:level="2"><nlm:aff id="aff15">Department of Pediatrics, Stanford University, Stanford, CA 94305;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Cobb, Joanna" sort="Cobb, Joanna" uniqKey="Cobb J" first="Joanna" last="Cobb">Joanna Cobb</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff29">National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Satorius, Colleen L" sort="Satorius, Colleen L" uniqKey="Satorius C" first="Colleen L." last="Satorius">Colleen L. Satorius</name><affiliation wicri:level="2"><nlm:aff id="aff2">Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Han, Buhm" sort="Han, Buhm" uniqKey="Han B" first="Buhm" last="Han">Buhm Han</name><affiliation wicri:level="2"><nlm:aff id="aff30">Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff31">Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736, Republic of Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736</wicri:regionArea><wicri:noRegion>138-736</wicri:noRegion></affiliation></author><author><name sortKey="Baskin, Elizabeth" sort="Baskin, Elizabeth" uniqKey="Baskin E" first="Elizabeth" last="Baskin">Elizabeth Baskin</name><affiliation wicri:level="2"><nlm:aff id="aff1">Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Signa, Sara" sort="Signa, Sara" uniqKey="Signa S" first="Sara" last="Signa">Sara Signa</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Pediatrics, University of Genova, 16145 Genoa, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pediatrics, University of Genova, 16145 Genoa</wicri:regionArea><wicri:noRegion>16145 Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><affiliation wicri:level="2"><nlm:aff id="aff33">Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff34">Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Achkar, J P" sort="Achkar, J P" uniqKey="Achkar J" first="J. P." last="Achkar">J. P. Achkar</name><affiliation wicri:level="2"><nlm:aff id="aff35">Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff36">Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathobiology, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><affiliation wicri:level="2"><nlm:aff id="aff33">Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Kaufman, Kenneth M" sort="Kaufman, Kenneth M" uniqKey="Kaufman K" first="Kenneth M." last="Kaufman">Kenneth M. Kaufman</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Kottyan, Leah C" sort="Kottyan, Leah C" uniqKey="Kottyan L" first="Leah C." last="Kottyan">Leah C. Kottyan</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Pinto, Dalila" sort="Pinto, Dalila" uniqKey="Pinto D" first="Dalila" last="Pinto">Dalila Pinto</name><affiliation wicri:level="2"><nlm:aff id="aff37">Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, NY 10029;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York</wicri:cityArea></affiliation></author><author><name sortKey="Scherer, Stephen W" sort="Scherer, Stephen W" uniqKey="Scherer S" first="Stephen W." last="Scherer">Stephen W. Scherer</name><affiliation wicri:level="1"><nlm:aff id="aff38">The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4</wicri:regionArea><wicri:noRegion>M5G 0A4</wicri:noRegion></affiliation></author><author><name sortKey="Alarc N Riquelme, Marta E" sort="Alarc N Riquelme, Marta E" uniqKey="Alarc N Riquelme M" first="Marta E." last="Alarc N-Riquelme">Marta E. Alarc N-Riquelme</name><affiliation wicri:level="2"><nlm:aff id="aff39">Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40">Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016</wicri:regionArea><wicri:noRegion>PTS Granada 18016</wicri:noRegion></affiliation></author><author><name sortKey="Docampo, Elisa" sort="Docampo, Elisa" uniqKey="Docampo E" first="Elisa" last="Docampo">Elisa Docampo</name><affiliation wicri:level="4"><nlm:aff id="aff41">Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège</wicri:regionArea><placeName><region type="province" nuts="2">Province de Liège</region><settlement type="city">Liège</settlement><settlement type="city">Liège</settlement></placeName><orgName type="university">Université de Liège</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff42">Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name><affiliation wicri:level="1"><nlm:aff id="aff42">Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gul, Ahmet" sort="Gul, Ahmet" uniqKey="Gul A" first="Ahmet" last="Gül">Ahmet Gül</name><affiliation wicri:level="1"><nlm:aff id="aff43">Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey;</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul</wicri:regionArea><wicri:noRegion>34390 Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><affiliation wicri:level="1"><nlm:aff id="aff44">Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX</wicri:regionArea><wicri:noRegion>3584 CX</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff45">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX</wicri:regionArea><wicri:noRegion>3584 CX</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff46">Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX</wicri:regionArea><wicri:noRegion>3584 CX</wicri:noRegion></affiliation></author><author><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff30">Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff31">Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Immunology, Allergy, and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Langefeld, Carl D" sort="Langefeld, Carl D" uniqKey="Langefeld C" first="Carl D." last="Langefeld">Carl D. Langefeld</name><affiliation wicri:level="2"><nlm:aff id="aff47">Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Susan" sort="Thompson, Susan" uniqKey="Thompson S" first="Susan" last="Thompson">Susan Thompson</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name><affiliation wicri:level="1"><nlm:aff id="aff3">Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA</wicri:regionArea><wicri:noRegion>CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Thomson, Wendy" sort="Thomson, Wendy" uniqKey="Thomson W" first="Wendy" last="Thomson">Wendy Thomson</name><affiliation wicri:level="4"><nlm:aff id="aff28">Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff29">National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Kastner, Daniel L" sort="Kastner, Daniel L" uniqKey="Kastner D" first="Daniel L." last="Kastner">Daniel L. Kastner</name><affiliation wicri:level="2"><nlm:aff id="aff2">Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Woo, Patricia" sort="Woo, Patricia" uniqKey="Woo P" first="Patricia" last="Woo">Patricia Woo</name><affiliation wicri:level="4"><nlm:aff id="aff25">Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA was <italic>HLA-DRB1*11</italic>, which conferred at least a two-fold increase in disease risk in each population studied. These data implicate the interaction of antigen presenting cells with T cells in the pathogenesis of sJIA.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Turquie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bavière</li><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>District de Basse-Franconie</li><li>District de Münster</li><li>Grand Londres</li><li>Grand Manchester</li><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Massachusetts</li><li>Ohio</li><li>Oklahoma</li><li>Ontario</li><li>Pennsylvanie</li><li>Province de Liège</li><li>Rhénanie-du-Nord-Westphalie</li><li>Utah</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Liège</li><li>Londres</li><li>Manchester</li><li>Münster</li><li>Toronto</li><li>Wurtzbourg</li></settlement><orgName><li>University College de Londres</li><li>Université de Barcelone</li><li>Université de Liège</li><li>Université de Manchester</li><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Ombrello, Michael J" sort="Ombrello, Michael J" uniqKey="Ombrello M" first="Michael J." last="Ombrello">Michael J. Ombrello</name></region><name sortKey="Achkar, J P" sort="Achkar, J P" uniqKey="Achkar J" first="J. P." last="Achkar">J. P. Achkar</name><name sortKey="Achkar, J P" sort="Achkar, J P" uniqKey="Achkar J" first="J. P." last="Achkar">J. P. Achkar</name><name sortKey="Alarc N Riquelme, Marta E" sort="Alarc N Riquelme, Marta E" uniqKey="Alarc N Riquelme M" first="Marta E." last="Alarc N-Riquelme">Marta E. Alarc N-Riquelme</name><name sortKey="Baskin, Elizabeth" sort="Baskin, Elizabeth" uniqKey="Baskin E" first="Elizabeth" last="Baskin">Elizabeth Baskin</name><name sortKey="Bohnsack, John F" sort="Bohnsack, John F" uniqKey="Bohnsack J" first="John F." last="Bohnsack">John F. Bohnsack</name><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><name sortKey="Grom, Alexei" sort="Grom, Alexei" uniqKey="Grom A" first="Alexei" last="Grom">Alexei Grom</name><name sortKey="Grom, Alexei" sort="Grom, Alexei" uniqKey="Grom A" first="Alexei" last="Grom">Alexei Grom</name><name sortKey="Han, Buhm" sort="Han, Buhm" uniqKey="Han B" first="Buhm" last="Han">Buhm Han</name><name sortKey="Han, Buhm" sort="Han, Buhm" uniqKey="Han B" first="Buhm" last="Han">Buhm Han</name><name sortKey="Ilowite, Norman T" sort="Ilowite, Norman T" uniqKey="Ilowite N" first="Norman T." last="Ilowite">Norman T. Ilowite</name><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><name sortKey="Kastner, Daniel L" sort="Kastner, Daniel L" uniqKey="Kastner D" first="Daniel L." last="Kastner">Daniel L. Kastner</name><name sortKey="Kaufman, Kenneth M" sort="Kaufman, Kenneth M" uniqKey="Kaufman K" first="Kenneth M." last="Kaufman">Kenneth M. Kaufman</name><name sortKey="Kaufman, Kenneth M" sort="Kaufman, Kenneth M" uniqKey="Kaufman K" first="Kenneth M." last="Kaufman">Kenneth M. Kaufman</name><name sortKey="Kottyan, Leah C" sort="Kottyan, Leah C" uniqKey="Kottyan L" first="Leah C." last="Kottyan">Leah C. Kottyan</name><name sortKey="Kottyan, Leah C" sort="Kottyan, Leah C" uniqKey="Kottyan L" first="Leah C." last="Kottyan">Leah C. Kottyan</name><name sortKey="Langefeld, Carl D" sort="Langefeld, Carl D" uniqKey="Langefeld C" first="Carl D." last="Langefeld">Carl D. Langefeld</name><name sortKey="Mellins, Elizabeth D" sort="Mellins, Elizabeth D" uniqKey="Mellins E" first="Elizabeth D." last="Mellins">Elizabeth D. Mellins</name><name sortKey="Park, Jane" sort="Park, Jane" uniqKey="Park J" first="Jane" last="Park">Jane Park</name><name sortKey="Pinto, Dalila" sort="Pinto, Dalila" uniqKey="Pinto D" first="Dalila" last="Pinto">Dalila Pinto</name><name sortKey="Prahalad, Sampath" sort="Prahalad, Sampath" uniqKey="Prahalad S" first="Sampath" last="Prahalad">Sampath Prahalad</name><name sortKey="Prahalad, Sampath" sort="Prahalad, Sampath" uniqKey="Prahalad S" first="Sampath" last="Prahalad">Sampath Prahalad</name><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><name sortKey="Remmers, Elaine F" sort="Remmers, Elaine F" uniqKey="Remmers E" first="Elaine F." last="Remmers">Elaine F. Remmers</name><name sortKey="Satorius, Colleen L" sort="Satorius, Colleen L" uniqKey="Satorius C" first="Colleen L." last="Satorius">Colleen L. Satorius</name><name sortKey="Thompson, Susan" sort="Thompson, Susan" uniqKey="Thompson S" first="Susan" last="Thompson">Susan Thompson</name><name sortKey="Thompson, Susan" sort="Thompson, Susan" uniqKey="Thompson S" first="Susan" last="Thompson">Susan Thompson</name><name sortKey="Zeft, Andrew S" sort="Zeft, Andrew S" uniqKey="Zeft A" first="Andrew S." last="Zeft">Andrew S. Zeft</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Tachmazidou, Ioanna" sort="Tachmazidou, Ioanna" uniqKey="Tachmazidou I" first="Ioanna" last="Tachmazidou">Ioanna Tachmazidou</name></noRegion><name sortKey="Cobb, Joanna" sort="Cobb, Joanna" uniqKey="Cobb J" first="Joanna" last="Cobb">Joanna Cobb</name><name sortKey="Cobb, Joanna" sort="Cobb, Joanna" uniqKey="Cobb J" first="Joanna" last="Cobb">Joanna Cobb</name><name sortKey="Hinks, Anne" sort="Hinks, Anne" uniqKey="Hinks A" first="Anne" last="Hinks">Anne Hinks</name><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><name sortKey="Thomson, Wendy" sort="Thomson, Wendy" uniqKey="Thomson W" first="Wendy" last="Thomson">Wendy Thomson</name><name sortKey="Thomson, Wendy" sort="Thomson, Wendy" uniqKey="Thomson W" first="Wendy" last="Thomson">Wendy Thomson</name><name sortKey="Wedderburn, Lucy R" sort="Wedderburn, Lucy R" uniqKey="Wedderburn L" first="Lucy R." last="Wedderburn">Lucy R. Wedderburn</name><name sortKey="Wedderburn, Lucy R" sort="Wedderburn, Lucy R" uniqKey="Wedderburn L" first="Lucy R." last="Wedderburn">Lucy R. Wedderburn</name><name sortKey="Woo, Patricia" sort="Woo, Patricia" uniqKey="Woo P" first="Patricia" last="Woo">Patricia Woo</name><name sortKey="Zeggini, Eleftheria" sort="Zeggini, Eleftheria" uniqKey="Zeggini E" first="Eleftheria" last="Zeggini">Eleftheria Zeggini</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Foell, Dirk" sort="Foell, Dirk" uniqKey="Foell D" first="Dirk" last="Foell">Dirk Foell</name></region><name sortKey="Haas, Johannes Peter" sort="Haas, Johannes Peter" uniqKey="Haas J" first="Johannes-Peter" last="Haas">Johannes-Peter Haas</name><name sortKey="Schwarz, Tobias" sort="Schwarz, Tobias" uniqKey="Schwarz T" first="Tobias" last="Schwarz">Tobias Schwarz</name></country><country name="Italie"><noRegion><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name></noRegion><name sortKey="Gattorno, Marco" sort="Gattorno, Marco" uniqKey="Gattorno M" first="Marco" last="Gattorno">Marco Gattorno</name><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><name sortKey="Signa, Sara" sort="Signa, Sara" uniqKey="Signa S" first="Sara" last="Signa">Sara Signa</name></country><country name="Turquie"><noRegion><name sortKey="Ozen, Seza" sort="Ozen, Seza" uniqKey="Ozen S" first="Seza" last="Özen">Seza Özen</name></noRegion><name sortKey="Bilginer, Yelda" sort="Bilginer, Yelda" uniqKey="Bilginer Y" first="Yelda" last="Bilginer">Yelda Bilginer</name><name sortKey="Gul, Ahmet" sort="Gul, Ahmet" uniqKey="Gul A" first="Ahmet" last="Gül">Ahmet Gül</name></country><country name="Argentine"><noRegion><name sortKey="Russo, Ricardo" sort="Russo, Ricardo" uniqKey="Russo R" first="Ricardo" last="Russo">Ricardo Russo</name></noRegion></country><country name="Brésil"><noRegion><name sortKey="Len, Claudio" sort="Len, Claudio" uniqKey="Len C" first="Claudio" last="Len">Claudio Len</name></noRegion><name sortKey="Hilario, Maria Odete E" sort="Hilario, Maria Odete E" uniqKey="Hilario M" first="Maria Odete E." last="Hilario">Maria Odete E. Hilario</name><name sortKey="Oliveira, Sheila" sort="Oliveira, Sheila" uniqKey="Oliveira S" first="Sheila" last="Oliveira">Sheila Oliveira</name></country><country name="Canada"><region name="Ontario"><name sortKey="Yeung, Rae S M" sort="Yeung, Rae S M" uniqKey="Yeung R" first="Rae S. M." last="Yeung">Rae S. M. Yeung</name></region><name sortKey="Rosenberg, Alan" sort="Rosenberg, Alan" uniqKey="Rosenberg A" first="Alan" last="Rosenberg">Alan Rosenberg</name><name sortKey="Scherer, Stephen W" sort="Scherer, Stephen W" uniqKey="Scherer S" first="Stephen W." last="Scherer">Stephen W. Scherer</name><name sortKey="Yeung, Rae S M" sort="Yeung, Rae S M" uniqKey="Yeung R" first="Rae S. M." last="Yeung">Rae S. M. Yeung</name><name sortKey="Yeung, Rae S M" sort="Yeung, Rae S M" uniqKey="Yeung R" first="Rae S. M." last="Yeung">Rae S. M. Yeung</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Anton, Jordi" sort="Anton, Jordi" uniqKey="Anton J" first="Jordi" last="Anton">Jordi Anton</name></region><name sortKey="Alarc N Riquelme, Marta E" sort="Alarc N Riquelme, Marta E" uniqKey="Alarc N Riquelme M" first="Marta E." last="Alarc N-Riquelme">Marta E. Alarc N-Riquelme</name><name sortKey="Docampo, Elisa" sort="Docampo, Elisa" uniqKey="Docampo E" first="Elisa" last="Docampo">Elisa Docampo</name><name sortKey="Estivill, Xavier" sort="Estivill, Xavier" uniqKey="Estivill X" first="Xavier" last="Estivill">Xavier Estivill</name></country><country name="Corée du Sud"><noRegion><name sortKey="Han, Buhm" sort="Han, Buhm" uniqKey="Han B" first="Buhm" last="Han">Buhm Han</name></noRegion></country><country name="Belgique"><region name="Province de Liège"><name sortKey="Docampo, Elisa" sort="Docampo, Elisa" uniqKey="Docampo E" first="Elisa" last="Docampo">Elisa Docampo</name></region></country><country name="Pays-Bas"><noRegion><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name></noRegion><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I. W." last="De Bakker">Paul I. W. De Bakker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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